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辛伐他汀片

  • 规      格:

    10mg

  • 重      量:

     

  • 批准文号:

    国药准字H20103439 

  • 用法(fa)用量:

    患(huan)(huan)(huan)者(zhe)(zhe)接受(shou)本(ben)(ben)(ben)品(pin)(pin)治(zhi)疗(liao)以前,应(ying)(ying)接受(shou)标准的(de)(de)(de)(de)(de)降(jiang)(jiang)(jiang)(jiang)胆(dan)固(gu)(gu)(gu)醇(chun)(chun)(chun)饮食(shi)并(bing)在(zai)治(zhi)疗(liao)过(guo)(guo)程中(zhong)(zhong)继续维(wei)持(chi)。 建议起(qi)(qi)(qi)始(shi)(shi)(shi)剂(ji)量(liang)(liang)为(wei)每(mei)(mei)(mei)天(tian)(tian)20mg,晚(wan)间一(yi)次(ci)服(fu)(fu)(fu)(fu)用(yong)(yong)(yong)(yong)(yong)。对于因存在(zai)冠(guan)心病(bing)(bing)、糖尿病(bing)(bing)、周围(wei)血(xue)管疾病(bing)(bing)、中(zhong)(zhong)风(feng)或(huo)(huo)其它脑血(xue)管疾病(bing)(bing)史而属于CHD事件(jian)高(gao)危人(ren)群的(de)(de)(de)(de)(de)患(huan)(huan)(huan)者(zhe)(zhe),推(tui)(tui)(tui)荐(jian)(jian)的(de)(de)(de)(de)(de)起(qi)(qi)(qi)始(shi)(shi)(shi)剂(ji)量(liang)(liang)为(wei)20~40mg/天(tian)(tian)。对于只需中(zhong)(zhong)度(du)降(jiang)(jiang)(jiang)(jiang)低(di)低(di)密度(du)脂(zhi)蛋白胆(dan)固(gu)(gu)(gu)醇(chun)(chun)(chun)的(de)(de)(de)(de)(de)患(huan)(huan)(huan)者(zhe)(zhe),起(qi)(qi)(qi)始(shi)(shi)(shi)剂(ji)量(liang)(liang)为(wei)10mg。对于同(tong)时(shi)(shi)(shi)服(fu)(fu)(fu)(fu)用(yong)(yong)(yong)(yong)(yong)环(huan)孢(bao)菌(jun)素(su)(su)、达那唑、贝(bei)特(te)类(非(fei)诺贝(bei)特(te)除外(wai))或(huo)(huo)烟酸(suan)类药物(wu)、胺碘(dian)酮、维(wei)拉帕(pa)米(mi)以及严重(zhong)肾功能(neng)不(bu)(bu)全的(de)(de)(de)(de)(de)病(bing)(bing)人(ren),其推(tui)(tui)(tui)荐(jian)(jian)剂(ji)量(liang)(liang)如(ru)下(xia): 推(tui)(tui)(tui)荐(jian)(jian)剂(ji)量(liang)(liang)范围(wei)为(wei)每(mei)(mei)(mei)天(tian)(tian)5~80mg,晚(wan)间一(yi)次(ci)服(fu)(fu)(fu)(fu)用(yong)(yong)(yong)(yong)(yong),所用(yong)(yong)(yong)(yong)(yong)剂(ji)量(liang)(liang)应(ying)(ying)根据基础(chu)低(di)密度(du)脂(zhi)蛋白胆(dan)固(gu)(gu)(gu)醇(chun)(chun)(chun)水(shui)平(ping)、推(tui)(tui)(tui)荐(jian)(jian)的(de)(de)(de)(de)(de)治(zhi)疗(liao)目标和患(huan)(huan)(huan)者(zhe)(zhe)反应(ying)(ying)进行个体(ti)(ti)化(hua)调(diao)整。调(diao)整剂(ji)量(liang)(liang)应(ying)(ying)间隔4周或(huo)(huo)以上。 应(ying)(ying)定期监测胆(dan)固(gu)(gu)(gu)醇(chun)(chun)(chun)水(shui)平(ping),当(dang)低(di)密度(du)脂(zhi)蛋白胆(dan)固(gu)(gu)(gu)醇(chun)(chun)(chun)水(shui)平(ping)降(jiang)(jiang)(jiang)(jiang)至75mg/dL(1.94mmol/L)或(huo)(huo)血(xue)浆总胆(dan)固(gu)(gu)(gu)醇(chun)(chun)(chun)水(shui)平(ping)降(jiang)(jiang)(jiang)(jiang)至140mg/dL (3.6mmol/L)以下(xia)时(shi)(shi)(shi),应(ying)(ying)考(kao)虑减少(shao)本(ben)(ben)(ben)品(pin)(pin)的(de)(de)(de)(de)(de)服(fu)(fu)(fu)(fu)用(yong)(yong)(yong)(yong)(yong)剂(ji)量(liang)(liang)。 -------纯(chun)合(he)子家(jia)族(zu)性(xing)高(gao)胆(dan)固(gu)(gu)(gu)醇(chun)(chun)(chun)血(xue)症(zheng) 根据一(yi)项(xiang)对照临床研究的(de)(de)(de)(de)(de)结果(guo),对纯(chun)合(he)子家(jia)族(zu)性(xing)高(gao)胆(dan)固(gu)(gu)(gu)醇(chun)(chun)(chun)血(xue)症(zheng)患(huan)(huan)(huan)者(zhe)(zhe),本(ben)(ben)(ben)品(pin)(pin)的(de)(de)(de)(de)(de)推(tui)(tui)(tui)荐(jian)(jian)剂(ji)量(liang)(liang)为(wei)每(mei)(mei)(mei)天(tian)(tian)40mg,晚(wan)间一(yi)次(ci)服(fu)(fu)(fu)(fu)用(yong)(yong)(yong)(yong)(yong);或(huo)(huo)每(mei)(mei)(mei)天(tian)(tian)80mg,分20mg、20mg和晚(wan)间40mg三次(ci)服(fu)(fu)(fu)(fu)用(yong)(yong)(yong)(yong)(yong)。本(ben)(ben)(ben)品(pin)(pin)可与其他(ta)降(jiang)(jiang)(jiang)(jiang)脂(zhi)疗(liao)法(fa)联(lian)合(he)应(ying)(ying)用(yong)(yong)(yong)(yong)(yong)(如(ru)低(di)密度(du)脂(zhi)蛋白提取法(fa)),当(dang)无法(fa)使用(yong)(yong)(yong)(yong)(yong)这些方法(fa)时(shi)(shi)(shi),也可单独使用(yong)(yong)(yong)(yong)(yong)本(ben)(ben)(ben)品(pin)(pin)。 ------服(fu)(fu)(fu)(fu)用(yong)(yong)(yong)(yong)(yong)环(huan)孢(bao)菌(jun)素(su)(su) 本(ben)(ben)(ben)品(pin)(pin)与环(huan)孢(bao)菌(jun)素(su)(su)同(tong)时(shi)(shi)(shi)服(fu)(fu)(fu)(fu)用(yong)(yong)(yong)(yong)(yong)时(shi)(shi)(shi)(见注意事项(xiang)中(zhong)(zhong)的(de)(de)(de)(de)(de)肌(ji)(ji)肉(rou)作用(yong)(yong)(yong)(yong)(yong)和药物(wu)相(xiang)(xiang)互(hu)作用(yong)(yong)(yong)(yong)(yong)),治(zhi)疗(liao)的(de)(de)(de)(de)(de)起(qi)(qi)(qi)始(shi)(shi)(shi)剂(ji)量(liang)(liang)为(wei)5mg/天(tian)(tian),不(bu)(bu)应(ying)(ying)超(chao)过(guo)(guo)10mg/天(tian)(tian)。 ------协同(tong)治(zhi)疗(liao) 本(ben)(ben)(ben)品(pin)(pin)单独应(ying)(ying)用(yong)(yong)(yong)(yong)(yong)或(huo)(huo)与胆(dan)酸(suan)螯合(he)剂(ji)协同(tong)应(ying)(ying)用(yong)(yong)(yong)(yong)(yong)时(shi)(shi)(shi)均有效。 若病(bing)(bing)人(ren)在(zai)服(fu)(fu)(fu)(fu)用(yong)(yong)(yong)(yong)(yong)本(ben)(ben)(ben)品(pin)(pin)时(shi)(shi)(shi),同(tong)时(shi)(shi)(shi)应(ying)(ying)用(yong)(yong)(yong)(yong)(yong)环(huan)孢(bao)菌(jun)素(su)(su)、达那唑、吉非(fei)贝(bei)齐或(huo)(huo)其它贝(bei)特(te)类(非(fei)诺贝(bei)特(te)除外(wai)),本(ben)(ben)(ben)品(pin)(pin)的(de)(de)(de)(de)(de)剂(ji)量(liang)(liang)不(bu)(bu)应(ying)(ying)超(chao)过(guo)(guo)每(mei)(mei)(mei)天(tian)(tian)10mg。若病(bing)(bing)人(ren)与本(ben)(ben)(ben)品(pin)(pin)一(yi)起(qi)(qi)(qi)同(tong)时(shi)(shi)(shi)服(fu)(fu)(fu)(fu)用(yong)(yong)(yong)(yong)(yong)胺碘(dian)酮或(huo)(huo)维(wei)拉帕(pa)米(mi),本(ben)(ben)(ben)品(pin)(pin)的(de)(de)(de)(de)(de)剂(ji)量(liang)(liang)不(bu)(bu)应(ying)(ying)超(chao)过(guo)(guo)每(mei)(mei)(mei)天(tian)(tian)20mg(见注意事项(xiang),肌(ji)(ji)病(bing)(bing)/横纹肌(ji)(ji)溶解(jie)和药物(wu)相(xiang)(xiang)互(hu)作用(yong)(yong)(yong)(yong)(yong))。 ----肾功能(neng)不(bu)(bu)全的(de)(de)(de)(de)(de)患(huan)(huan)(huan)者(zhe)(zhe) 由于本(ben)(ben)(ben)品(pin)(pin)经肾脏排泄不(bu)(bu)明显,故轻、中(zhong)(zhong)度(du)肾功能(neng)不(bu)(bu)全患(huan)(huan)(huan)者(zhe)(zhe)不(bu)(bu)需调(diao)整剂(ji)量(liang)(liang)。然而,对于严重(zhong)肾功能(neng)不(bu)(bu)全的(de)(de)(de)(de)(de)患(huan)(huan)(huan)者(zhe)(zhe)(肌(ji)(ji)酐清(qing)除率<30ml/分钟)应(ying)(ying)慎用(yong)(yong)(yong)(yong)(yong)本(ben)(ben)(ben)品(pin)(pin),此(ci)类患(huan)(huan)(huan)者(zhe)(zhe)的(de)(de)(de)(de)(de)起(qi)(qi)(qi)始(shi)(shi)(shi)剂(ji)量(liang)(liang)应(ying)(ying)为(wei)每(mei)(mei)(mei)天(tian)(tian)5mg,并(bing)密切监测。 ----杂(za)合(he)子家(jia)族(zu)性(xing)高(gao)胆(dan)固(gu)(gu)(gu)醇(chun)(chun)(chun)血(xue)症(zheng)儿童(tong)患(huan)(huan)(huan)者(zhe)(zhe)(10~17岁) 对杂(za)合(he)子家(jia)族(zu)性(xing)高(gao)胆(dan)固(gu)(gu)(gu)醇(chun)(chun)(chun)血(xue)症(zheng)10~17岁的(de)(de)(de)(de)(de)儿童(tong)患(huan)(huan)(huan)者(zhe)(zhe),本(ben)(ben)(ben)品(pin)(pin)推(tui)(tui)(tui)荐(jian)(jian)的(de)(de)(de)(de)(de)起(qi)(qi)(qi)始(shi)(shi)(shi)剂(ji)量(liang)(liang)为(wei)每(mei)(mei)(mei)天(tian)(tian)10mg,晚(wan)间一(yi)次(ci)服(fu)(fu)(fu)(fu)用(yong)(yong)(yong)(yong)(yong)。推(tui)(tui)(tui)荐(jian)(jian)的(de)(de)(de)(de)(de)剂(ji)量(liang)(liang)范围(wei)为(wei)每(mei)(mei)(mei)天(tian)(tian)10~40mg,推(tui)(tui)(tui)荐(jian)(jian)的(de)(de)(de)(de)(de)最大剂(ji)量(liang)(liang)为(wei)每(mei)(mei)(mei)天(tian)(tian)40mg。所用(yong)(yong)(yong)(yong)(yong)剂(ji)量(liang)(liang)应(ying)(ying)根据推(tui)(tui)(tui)荐(jian)(jian)的(de)(de)(de)(de)(de)治(zhi)疗(liao)目标进行个体(ti)(ti)化(hua)调(diao)整(见药理(li)毒(du)理(li))。 

  • 成      份(fen):

    本品活性成份为辛伐(fa)他汀(ting),其化学(xue)名称为2,2-二(er)甲(jia)基(ji)丁酸 (4R,6R)-6- [2-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8α-六氢(qing)-8-羟(qiang)基(ji)-2,6-二(er)甲(jia)基(ji)-1-萘基(ji)]乙基(ji)]四氢(qing)-4-羟(qiang)基(ji)-2H-吡喃-2-酮(tong)-8-酯。 

  • 功能主治:

    高(gao)(gao)(gao)(gao)脂(zhi)血(xue)(xue)(xue)(xue)(xue)症(zheng) 对(dui)于(yu)原(yuan)发(fa)性(xing)高(gao)(gao)(gao)(gao)胆(dan)(dan)(dan)(dan)固(gu)醇(chun)(chun)(chun)(chun)(chun)血(xue)(xue)(xue)(xue)(xue)症(zheng)、杂合子(zi)(zi)(zi)家族性(xing)高(gao)(gao)(gao)(gao)胆(dan)(dan)(dan)(dan)固(gu)醇(chun)(chun)(chun)(chun)(chun)血(xue)(xue)(xue)(xue)(xue)症(zheng)或混(hun)合性(xing)高(gao)(gao)(gao)(gao)胆(dan)(dan)(dan)(dan)固(gu)醇(chun)(chun)(chun)(chun)(chun)血(xue)(xue)(xue)(xue)(xue)症(zheng)的(de)患(huan)(huan)者(zhe),当饮(yin)(yin)食(shi)控(kong)(kong)(kong)制(zhi)及(ji)其它非(fei)药物治疗不理想时(shi),结(jie)合饮(yin)(yin)食(shi)控(kong)(kong)(kong)制(zhi),本品可(ke)(ke)用于(yu)降(jiang)(jiang)低(di)升(sheng)高(gao)(gao)(gao)(gao)的(de)总(zong)(zong)胆(dan)(dan)(dan)(dan)固(gu)醇(chun)(chun)(chun)(chun)(chun)、低(di)密(mi)度脂(zhi)蛋(dan)(dan)(dan)(dan)(dan)白(bai)(bai)(bai)胆(dan)(dan)(dan)(dan)固(gu)醇(chun)(chun)(chun)(chun)(chun)、载(zai)脂(zhi)蛋(dan)(dan)(dan)(dan)(dan)白(bai)(bai)(bai)B和(he)甘油三(san)酯(zhi),且可(ke)(ke)升(sheng)高(gao)(gao)(gao)(gao)高(gao)(gao)(gao)(gao)密(mi)度脂(zhi)蛋(dan)(dan)(dan)(dan)(dan)白(bai)(bai)(bai)胆(dan)(dan)(dan)(dan)固(gu)醇(chun)(chun)(chun)(chun)(chun),从(cong)而降(jiang)(jiang)低(di)低(di)密(mi)度脂(zhi)蛋(dan)(dan)(dan)(dan)(dan)白(bai)(bai)(bai)胆(dan)(dan)(dan)(dan)固(gu)醇(chun)(chun)(chun)(chun)(chun)/高(gao)(gao)(gao)(gao)密(mi)度脂(zhi)蛋(dan)(dan)(dan)(dan)(dan)白(bai)(bai)(bai)胆(dan)(dan)(dan)(dan)固(gu)醇(chun)(chun)(chun)(chun)(chun)及(ji)总(zong)(zong)胆(dan)(dan)(dan)(dan)固(gu)醇(chun)(chun)(chun)(chun)(chun)/高(gao)(gao)(gao)(gao)密(mi)度脂(zhi)蛋(dan)(dan)(dan)(dan)(dan)白(bai)(bai)(bai)胆(dan)(dan)(dan)(dan)固(gu)醇(chun)(chun)(chun)(chun)(chun)的(de)比率。 对(dui)于(yu)纯合子(zi)(zi)(zi)家族性(xing)高(gao)(gao)(gao)(gao)胆(dan)(dan)(dan)(dan)固(gu)醇(chun)(chun)(chun)(chun)(chun)血(xue)(xue)(xue)(xue)(xue)症(zheng)患(huan)(huan)者(zhe),结(jie)合饮(yin)(yin)食(shi)控(kong)(kong)(kong)制(zhi)及(ji)非(fei)饮(yin)(yin)食(shi)疗法,本品可(ke)(ke)用于(yu)降(jiang)(jiang)低(di)升(sheng)高(gao)(gao)(gao)(gao)的(de)总(zong)(zong)胆(dan)(dan)(dan)(dan)固(gu)醇(chun)(chun)(chun)(chun)(chun)、低(di)密(mi)度脂(zhi)蛋(dan)(dan)(dan)(dan)(dan)白(bai)(bai)(bai)胆(dan)(dan)(dan)(dan)固(gu)醇(chun)(chun)(chun)(chun)(chun)和(he)载(zai)脂(zhi)蛋(dan)(dan)(dan)(dan)(dan)白(bai)(bai)(bai)B。 冠(guan)心病 对(dui)于(yu)冠(guan)心病合并(bing)高(gao)(gao)(gao)(gao)胆(dan)(dan)(dan)(dan)固(gu)醇(chun)(chun)(chun)(chun)(chun)血(xue)(xue)(xue)(xue)(xue)症(zheng)的(de)患(huan)(huan)者(zhe),本品适用于(yu): 降(jiang)(jiang)低(di)死亡的(de)危险(xian)性(xing)。 降(jiang)(jiang)低(di)冠(guan)心病死亡及(ji)非(fei)致死性(xing)心肌梗塞的(de)危险(xian)性(xing)。 降(jiang)(jiang)低(di)中风和(he)短(duan)暂(zan)性(xing)脑(nao)缺血(xue)(xue)(xue)(xue)(xue)的(de)危险(xian)性(xing)。 降(jiang)(jiang)低(di)心脏血(xue)(xue)(xue)(xue)(xue)管重建手术(shu)(冠(guan)状动脉搭(da)桥(qiao)术(shu)及(ji)经皮腔内冠(guan)状动脉成形术(shu))的(de)危险(xian)性(xing)。 延缓(huan)冠(guan)状动脉粥样硬化(hua)的(de)进程,包括(kuo)减(jian)少(shao)新病灶及(ji)全堵塞的(de)形成。 患(huan)(huan)有杂合子(zi)(zi)(zi)家族性(xing)高(gao)(gao)(gao)(gao)胆(dan)(dan)(dan)(dan)固(gu)醇(chun)(chun)(chun)(chun)(chun)血(xue)(xue)(xue)(xue)(xue)症(zheng)儿童患(huan)(huan)者(zhe) 对(dui)于(yu)患(huan)(huan)有杂合子(zi)(zi)(zi)家族性(xing)高(gao)(gao)(gao)(gao)胆(dan)(dan)(dan)(dan)固(gu)醇(chun)(chun)(chun)(chun)(chun)血(xue)(xue)(xue)(xue)(xue)症(zheng)的(de)10~17岁的(de)青春期男孩(hai)和(he)女孩(hai)(至少(shao)初潮1年(nian)后),结(jie)合饮(yin)(yin)食(shi)控(kong)(kong)(kong)制(zhi),本品可(ke)(ke)用于(yu)降(jiang)(jiang)低(di)总(zong)(zong)胆(dan)(dan)(dan)(dan)固(gu)醇(chun)(chun)(chun)(chun)(chun)、低(di)密(mi)度脂(zhi)蛋(dan)(dan)(dan)(dan)(dan)白(bai)(bai)(bai)胆(dan)(dan)(dan)(dan)固(gu)醇(chun)(chun)(chun)(chun)(chun)、载(zai)脂(zhi)蛋(dan)(dan)(dan)(dan)(dan)白(bai)(bai)(bai)B和(he)甘油三(san)酯(zhi)。 

详情描述

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